منابع مشابه
Warburg revisited: lessons for innate immunity and sepsis
Citation: Srivastava A and Mannam P (2015) Warburg revisited: lessons for innate immunity and sepsis. A Commentary on mTOR-and HIF-1-mediated aerobic glycolysis as metabolic basis for trained immunity Warburg effect was first described as a mechanism by which the tumor cells rely on glycoly-sis to power proliferation and biosynthesis (Hsu and Sabatini, 2008). The transcription factor, hypoxia-i...
متن کاملWarburg revisited: imaging tumour blood flow and metabolism
In the 1930s, Otto Warburg reported that anaerobic metabolism of glucose is a fundamental property of all tumours, even in the presence of an adequate oxygen supply. He also demonstrated a relationship between the degree of anaerobic metabolism and tumour growth rate. Today, this phenomenon forms the basis of tumour imaging with fluorodeoxyglucose positron emission tomography (FDG-PET). More re...
متن کاملPartners in the Warburg effect
Cells that surround tumors produce vesicles that supply nutrients to cancer cells and, more surprisingly, also impair the generation of energy in these cancer cells.
متن کاملWarburg effect or reverse Warburg effect? A review of cancer metabolism.
Cancer is a major threat to human health. A considerable amount of research has focused on elucidating the nature of cancer from its pathogenesis to treatment and prevention. Tumor cell metabolism has been considered a hallmark of cancer. Cancer cells differ from normal cells through unlimited cell division, and show a greater need for energy for their rapid growth and duplication. Research on ...
متن کاملmTORC2 dictates Warburg effect and drug resistance
Metabolic reprogramming, a prominent phenotype in cancer cells, is the adaptation to shifts in the usage of metabolites, including glucose, fatty acids, amino acids, and glutamine. The central feature of this adaptation lies in the fact that cancer cells undergo glycolysis even in the presence of ample oxygen, contrary to normal cells. This aerobic glycolysis, termed “the Warburg effect,” has b...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2008
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc2364